Prospect of the hottest pentaphenylacetic acid sit

  • Detail

Phenylacetic acid is an important fine chemical intermediate, which is widely used in medicine, pesticides, spices, dyes and other fields

there are two main routes for the industrial synthesis of phenylacetic acid at home and abroad, one is phenylacetonitrile hydrolysis. This method is a traditional production method. Due to the use of highly toxic sodium cyanide as raw material, the pollution is serious, the amount of "three wastes" is large, and the product quality is poor, which affects the application of subsequent products. The yield is low and faces elimination. However, this method is mainly used in domestic production at present. The second is the carbonylation of benzyl chloride. This is a new phenylacetic acid production technology developed in recent ten years. The reaction conditions are mild, sodium cyanide is avoided, the yield is high, the raw materials are easy to obtain, and the purity of CO is not high. Industrial waste gases rich in CO, such as yellow phosphorus tail gas, closed calcium carbide furnace gas, 2 The regeneration gas from copper washing in green ammonia plant and the tail gas from converter steelmaking can be used to prepare phenylacetic acid after recovery. In the 1980s, the research on Chlorobenzyl carbonylation of p-phenylacetic acid abroad was very active. At present, Germany, Japan, Italy and other countries have adopted this method for industrial production. In recent years, a number of domestic scientific research institutions have studied this process and made substantial breakthroughs and progress. Four sets of Chlorobenzyl carbonylation industrial units have been built in China. The key of this method lies in the selection and recovery of catalysts. At present, the main catalyst used in China is carbonyl cobalt

at present, there are nearly 30 phenylacetic acid manufacturers in China, with a total annual production capacity of about 20000 tons. Most of the enterprises are small-scale, with the largest annual production of 2000 tons, and most of the others are hundreds of tons; The process technology is backward. More than 80% of enterprises adopt phenylacetonitrile hydrolysis method, which has high production cost and serious pollution of "three wastes"; The product quality is poor, and the use of downstream products is affected because the product is prone to toxic cyanide. Therefore, many enterprises are in the state of shutdown or semi shutdown, with an output of about 12000 tons in 2000. Domestic Shijiazhuang chemical plant, Jining electrochemical plant, Deyuan fine chemical plant and Suihua chemical fertilizer plant are produced by Chlorobenzyl carbonylation method, with a total annual production capacity of about 3000 tons

phenylacetic acid is mainly used as an intermediate in medicine, pesticides and spices. In 2000, the consumption of phenylacetic acid in China was 11200 tons. The consumption proportion is: medicine accounts for 88%, pesticides account for 3%, spices account for 7%, exports and others account for 2%. In medicine, the main contact of phenylacetic acid: Mr. Qian 15316888628 is used to prepare penicillin g salt; Secondly, it is used to prepare sedative and antiepileptic drugs phenobarbital and promethasone, antidepressant amitriptyline, cardiovascular drugs cardioclonidine lactate, Dibazol, clomiprazole, anticholinergic drugs atropine, antispasmodin, antirheumatic drugs and appetite inhibitors. Among them, penicillin for synthesis accounts for 85% of the total consumption of phenylacetic acid, and other drugs account for 3%. China is the main producer and exporter of penicillin G in the world. Due to the difficulty of penicillin production process and the serious pollution of "three wastes", famous western manufacturers have stopped production, bringing good development opportunities to our country. China's penicillin output increased from 2000 tons in 1990 to 12000 tons in 2000, accounting for about 25% of the world's total output. In previous years, due to the rapid increase of penicillin in India and rampant smuggling activities, the export price of penicillin in China continued to decline, which seriously affected the development of the domestic phenylacetic acid market. Since last year, the world penicillin market has gradually improved and the price has been rising. China's entry into WTO is imminent, and the export situation of penicillin will become better and better in the future. In addition, in recent years, the domestic research and application of penicillin side chain compounds are very active, adding β- Lactamase inhibitors can improve the efficacy of penicillin and reduce the impact of drug resistance. In addition, the national electrode material design takes into account the comprehensive factors to carry out the reform of the staff medical system. Its efficacy is accurate and the price is low. Penicillin has become the first choice of antibiotics. It is expected that penicillin will be difficult to shake its leading position in China for a long time. In turn, the domestic consumption of antibiotics will increase to a certain extent in the future. The consumption of phenylacetic acid in other drugs is small, and the demand will not increase significantly in the next few years. It is estimated that the pharmaceutical industry in China will consume about 40000 tons of phenylacetic acid in 2005

in terms of pesticides, phenylacetic acid can be used to prepare pesticides such as daofengsan, trichlorfon, fungicide benshuangling, herbicide trichlorophenyl acetic acid, rodenticide Dalong, rodenticide, chloramphenicol, etc. The pesticide industry consumed about 340 tons of phenylacetic acid in 2000. As the consumption of pesticide industry is less, and most of the pesticides produced are traditional pesticides, there will be no significant growth in the future. It is estimated that China's pesticide industry will consume 500 tons of phenylacetic acid in 2005

in terms of flavor, phenylacetate is an edible flavor permitted by China's regulations. As a substitute for indole or civet fragrance, it can be mixed with aroma types such as Acacia, osmanthus, rose, and aromatic essence. It is mainly used in the production of food, detergent, detergent, cosmetics, tobacco, beverages, etc. Moreover, phenylacetate also has the aromatherapy effect of controlling appetite, which has a good clinical effect on the adjuvant treatment of obesity. According to relevant data, the consumption of spices in developed regions such as Europe and the United States accounts for more than 30% of the demand for phenylacetic acid. Phenylacetic acid ester spices occupy a very important position in ester spices in the international market, and the demand is increasing year by year. Due to insufficient attention to the development of downstream products in China, only a few enterprises produce phenylacetate series products at present. It is expected that in the future, the spice industry will be the field with rapid growth of phenylacetic acid consumption in China, and the demand for phenylacetic acid will be about 2000 tons in 2005

in addition, phenylacetic acid can also be used in high-performance engineering plastics, fluorescent brighteners, dyes, liquid crystal materials and other fields. With the increasing pressure of environmental protection and the rapid development of fine chemical industry in China, the price of phenylacetic acid decreases, and some products with phenylacetonitrile as raw material may turn to phenylacetic acid. Therefore, the demand for phenylacetic acid in the field of fine organic synthesis may increase at a faster rate. In the past, phenylacetic acid has been a relatively scarce intermediate in China, and thousands of tons of phenylacetic acid need to be imported from abroad every year to meet domestic demand. Stimulated by the huge market demand, there was an upsurge of construction of phenylacetic acid in China in the early 1990s. The output increased year by year, and the import volume decreased day by day. In 2000, there was almost no import, and about 150 tons were exported. Due to environmental pressure and other factors, developed countries in the world have restricted the development of chlorine organic products, and their enthusiasm for new construction or expansion is not high, even decreasing year by year. Therefore, the export prospect of phenylacetic acid in China is promising. It is estimated that the demand and export volume of phenylacetic acid in other fields in 2005 will be about 1500 tons

phenylacetic acid is a fine chemical intermediate with considerable production capacity in China, but the product quality and synthesis technology cannot meet the future development needs. China's entry into WTO is approaching, and the export prospect of phenylacetic acid and its downstream products is getting better and better. Therefore, the following suggestions are put forward for the development of phenylacetic acid industry in China: first, with the increasingly mature technology of benzyl chloride carbonylation to synthesize phenylacetic acid, domestic manufacturers should work with scientific research departments to improve and perfect the technology of benzyl chloride carbonylation, and use this method to transform the phenylacetonitrile hydrolysis unit. Qualified enterprises can use benzyl chloride carbonylation method to build large-scale production units as soon as possible. Second, the domestic price of benzyl chloride, the raw material for phenylacetic acid production, is low and the supply is sufficient, which can provide raw material guarantee for phenylacetic acid production. Therefore, China should vigorously develop the downstream products of phenylacetic acid, especially the development and application of phenylacetate series products. At the same time, we should speed up the pace of phenylacetic acid replacing phenylacetonitrile and promote the production and consumption of phenylacetic acid. Third, while strengthening production, seize the opportunity to occupy the international market with high-quality and low-cost products, because efforts to expand product exports are one of the important driving forces for the development of phenylacetic acid in China

Copyright © 2011 JIN SHI